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EGFR mutation: novel prognostic factor associated with immune infiltration in lower-grade glioma; an exploratory study.

Zhaonian HaoDongsheng Guo
Published in: BMC cancer (2019)
EGFR mutation indicates increasing infiltration of specific types of immune cells and poor prognosis in lower-grade glioma. Alteration of immune microenvironment since the EGFR mutation might influence the survival of glioma. We also provided a novel evidence and indicator of PD-1 inhibitor application in glioma.
Keyphrases
  • poor prognosis
  • small cell lung cancer
  • epidermal growth factor receptor
  • prognostic factors
  • tyrosine kinase
  • long non coding rna
  • stem cells