The rs78378222 prevalence and the copy loss of the protective allele A in the tumor tissue of diffuse large B-cell lymphoma.
Elena N VoropaevaYuriy L OrlovTatiana I PospelovaAnna A GuragevaMikhail I VoevodaVladimir N MaksimovOlga B SereginaMaria I ChurkinaPublished in: PeerJ (2020)
At the stages of DLBCL initiation or progression a loss of the protective allele A of rs78378222 occurs. Further efforts are needed to study possible molecular mechanisms underlying somatic alterations in DLBCL in this region of the TP53 3'-UTR as well as functional studies to illustrate how the presents of rs78378222 may affect tumor progression of lymphoma.