Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A.

Yoon Jeong ChoiJun Bon KooHee Yeon KimJin Won SeoEun Jeong LeeWoo Ram KimJoo Young ChoKi Baik HahmSung Pyo HongDuk Hwan KimJun Hwan Yoo

Published in: Stem cell research & therapy (2019)

UC/PL-MSCs suppress TGF-β1-induced fibrogenic activation in HIMFs by blocking the Rho/MRTF/SRF pathway and could be considered as a novel candidate for stem cell-based therapy of intestinal fibrosis.

Keyphrases

umbilical cord
mesenchymal stem cells
stem cells
transcription factor
endothelial cells
high glucose
diabetic rats
induced pluripotent stem cells
transforming growth factor
drug induced
smooth muscle
pluripotent stem cells
signaling pathway
protein kinase