High end-of-treatment hepatitis B core-related antigen levels predict hepatitis flare after stopping nucleot(s)ide analogue therapy.
Simon John HumeDanny K WongMan Fung YuenKathy JacksonSara BonanzingaSara VogrinSamuel A L HallGareth S BurnsPaul V DesmondVijaya SundararajanDilip RatnamMiriam T LevyJohn S LubelAmanda J NicollSimone Irene StrasserWilliam SievertMeng C NguMarie SinclairChristopher MeredithGail MatthewsPeter A RevillMargaret LittlejohnScott BowdenKumar VisvanathanJacinta A HolmesAlexander J ThompsonPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
High levels of serum HBcrAg predict for hepatitis flare after stopping NA therapy and low likelihood of HBsAg loss at week 96. People with high levels of serum HBcrAg are not suitable candidates for NA discontinuation.