Buyang Huanwu Decoction Exerts Cardioprotective Effects through Targeting Angiogenesis via Caveolin-1/VEGF Signaling Pathway in Mice with Acute Myocardial Infarction.
Jia-Zhen ZhuXiao-Yi BaoQun ZhengQiang TongPeng-Chong ZhuZhuang ZhuangYan WangPublished in: Oxidative medicine and cellular longevity (2019)
Compared with the AMI group, the BHD-treated group showed a significant improvement in the heart weight/body weight ratio, echocardiography images, cardiac function, infarct size, Mason staining of the collagen deposition area, and density of microvessel in the infarction border zone (P < 0.05). Compared with the AMI group, BHD promoted the expression of Cav-1, VEGF, VEGFR2, and p-ERK in the infarction border zone after AMI. BHD could exert cardioprotective effects on the mouse model with AMI through targeting angiogenesis via Cav-1/VEGF signaling pathway.
Keyphrases
- acute myocardial infarction
- vascular endothelial growth factor
- signaling pathway
- endothelial cells
- body weight
- left ventricular
- percutaneous coronary intervention
- pi k akt
- mouse model
- epithelial mesenchymal transition
- cancer therapy
- poor prognosis
- heart failure
- induced apoptosis
- body mass index
- physical activity
- deep learning
- pulmonary hypertension
- wound healing
- convolutional neural network
- weight loss
- cell proliferation
- computed tomography
- atrial fibrillation
- acute coronary syndrome
- coronary artery disease
- insulin resistance
- drug delivery