2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis.

C-Y LinY-T ChinP-J KuoH-W LeeHaw-Ming HuangH-Y LinI-T WengC-N HsiungY-H ChanSheng-Yang Lee

Published in: International endodontic journal (2018)

2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside treatment enhanced the renewal ability and proliferative potential of hDPSCs via the AMPK/ERK/SIRT1 axis, which may provide a novel autogenic cell-based therapeutic strategy in regenerative dentistry.

Keyphrases

stem cells
cell therapy
signaling pathway
cell proliferation
skeletal muscle
endothelial cells
pi k akt
oxidative stress
ischemia reperfusion injury
mesenchymal stem cells
single cell
protein kinase
induced pluripotent stem cells
pluripotent stem cells