Praliciguat Promotes Ischemic Leg Reperfusion on Leptin Receptor-Deficient Mice.

Ninon Foussard Paul Rouault Lauriane CornuaultAnnabel ReynaudEmmanuel S BuysCandice Chapouly Alain-Pierre Gadeau Thierry CouffinhalKamel MohammediMarie-Ange Renault

Published in: Circulation research (2022)

Our results demonstrated that praliciguat promotes blood flow recovery in the ischemic muscle of mice with type 2 diabetes, at least in part by increasing arteriole diameter and by downregulating ICAM1 expression.

Keyphrases

blood flow
cerebral ischemia
poor prognosis
ischemia reperfusion injury
binding protein
skeletal muscle
heart failure
high fat diet induced
acute ischemic stroke
oxidative stress
adipose tissue
coronary artery disease
metabolic syndrome
left ventricular
optic nerve
insulin resistance