Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects.
Debra J TompsonCarwyn DaviesNicola E ScottEdward P CannonsMichalis S KostapanosAnnette S GrossMarcy PowellHiroko InoRyutaro ShimamuraHirofumi OguraTakashi NagakuboHarue IgarashiAtsushi NakanoPublished in: European journal of drug metabolism and pharmacokinetics (2021)
The pharmacokinetics and tolerability of GSK2982772 were similar between Western and Japanese subjects, justifying inclusion of Japanese subjects in future global clinical studies to assess the therapeutic potential of RIPK1 inhibition for the treatment of IMIDs. Clinical Trials: NCT03305419 and NCT03590613 available from http://www.clinicaltrials.gov .