Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.

Li XiangWenxu PanHuan ChenWenjun DuShuping XieXinhua LiangFangying YangRongwei NiuCanxin HuangMinan LuoYuxin XuLanlan GengSitang GongWanfu Xu Junhong Zhao

Published in: Mediators of inflammation (2024)

These findings suggested that sorbitol suppressed intestinal enteroids and M-cell differentiation and matured through PDE4-mediated RANKL expression; targeting to inhibit PDE4 was sufficient to induce M-cell development.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
endoplasmic reticulum stress
cell death
single cell
oxidative stress
cell therapy
cancer therapy
nuclear factor
bone loss
cell proliferation
drug delivery