Macrophage-derived apoptotic bodies impair the osteogenic ability of osteoblasts in periodontitis.

Xu LiuLijia GuoJuan DuZhenhua LuoJunji XuUjjal Kumar BhawalXiaoyan LiYi Liu

Published in: Oral diseases (2023)

Macrophage-derived ABs inhibit osteoblast differentiation via the transfer of miR-483-5p, which downregulates Col1A1 expression and finally suppresses osteogenic activity.

Keyphrases

mesenchymal stem cells
bone marrow
adipose tissue
poor prognosis
cell death
signaling pathway
anti inflammatory
long non coding rna
electron transfer