Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo.
Carmela CiccarelliAgnese Di RoccoGiovanni Luca GravinaAnnunziata MauroClaudio FestucciaAndrea Del FattorePaolo BerardinelliFrancesca De FeliceDaniela MusioMarina BouchéVincenzo TomboliniBianca Maria ZaniFrancesco MaramponPublished in: Journal of cancer research and clinical oncology (2018)
The results of our study suggest that signal transduction-based therapy can, by disrupting the MEK/ERK/c-Myc axis, reduce human PCa radioresistance caused by increased c-Myc expression in vivo and in vitro and restores apoptosis signals.