Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC.
Richard P BaumAviral SinghMartina BenešováChristiaan VermeulenSilvano GnesinUlli KoesterKarl JohnstonDirk MüllerStefan SenftlebenHarshad V KulkarniAndreas TürlerRoger SchibliJohn O PriorNicholas P van der MeulenCristina MüllerPublished in: Dalton transactions (Cambridge, England : 2003) (2018)
The existence of theragnostic pairs of radionuclides allows the preparation of radiopharmaceuticals for diagnostic and therapeutic purposes. Radiolanthanides, such as 177Lu, are successfully used for therapeutic purposes; however, a perfect diagnostic match is currently not available for clinical use. A unique, multi-disciplinary study was performed using 152Tb (T1/2 = 17.5 h, Eβ+average = 1140 keV, Iβ+ = 20.3%), which resulted in the first-in-human PET/CT images with this promising radionuclide. For this purpose, 152Tb was produced via a spallation process followed by mass separation at ISOLDE, CERN. The chemical separation and quality control, performed at PSI, resulted in a pure product in sufficient yields. Clinical PET phantom studies revealed an increased image noise level, because of the smaller β+ branching ratio of 152Tb as compared to standard PET nuclides at matched activity concentrations; however, the expected recovery would be comparable at matched signal-to-noise ratios in clinical PET. 152Tb was used for labeling DOTATOC, at Zentralklinik Bad Berka, and administered to a patient for a first-in-human clinical study. PET scans were performed over a period of 24 h, allowing the visualization of even small metastases with increased tumor-to-background contrast over time. Based on the results obtained in this work, it can be deduced that PET/CT imaging with 152Tb-labeled targeting agents has promise for clinical application and may be particularly interesting for pre-therapeutic dosimetry.
Keyphrases
- pet ct
- mycobacterium tuberculosis
- endothelial cells
- positron emission tomography
- quality control
- induced pluripotent stem cells
- pluripotent stem cells
- computed tomography
- clinical evaluation
- air pollution
- high resolution
- magnetic resonance
- magnetic resonance imaging
- clinical trial
- machine learning
- case report
- big data
- cancer therapy
- liquid chromatography
- optical coherence tomography
- contrast enhanced
- simultaneous determination