Assessing the value of incorporating a polygenic risk score with non-genetic factors for predicting breast cancer diagnosis in the UK Biobank.

Jennifer A Collister Xiaonan Liu Thomas J Littlejohns Jack M Cuzick Lei Clifton David J Hunter

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2024)

These findings could have important implications for the ongoing discussion about the value of PRS in risk prediction models and screening.

Keyphrases

genome wide
cross sectional
copy number
gene expression
dna methylation
breast cancer risk