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Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study.

Elisha M WachmanAlice WangBreanna C IsleyJeffery BoatengJacob A BeierleAaron HansburyHira ShresthaCamron BryantHuiping Zhang
Published in: Exploration of medicine (2020)
No significant associations were found between OPRM1 placental DNA methylation levels and NOWS severity in this pilot cohort. In addition, no significant differences were seen in OPRM1 methylation in opioid versus control placentas. Future association studies examining methylation levels on a genome-wide level are warranted.
Keyphrases
  • dna methylation
  • genome wide
  • chronic pain
  • pain management
  • gene expression
  • copy number
  • case report
  • current status
  • randomized controlled trial
  • clinical trial
  • case control