DNA condensation in live E. coli provides evidence for transertion.

Anil K GorleAmy L BottomleyElizabeth J HarryJ Grant CollinsF Richard KeeneClifford E Woodward

Published in: Molecular bioSystems (2017)

Condensation studies of chromosomal DNA in E. coli with a tetranuclear ruthenium complex are carried out and images obtained with wide-field fluorescence microscopy. Remarkably different condensate morphologies resulted, depending upon the treatment protocol. The occurrence of condensed nucleoid spirals in live bacteria provides evidence for the transertion hypothesis.

Keyphrases

single molecule
circulating tumor
escherichia coli
cell free
optical coherence tomography
randomized controlled trial
risk assessment
deep learning
convolutional neural network
high throughput
nucleic acid
machine learning
copy number
gene expression
combination therapy
dna methylation
label free