IL-13 induced inflammation increases DPP4 abundance but does not enhance MERS-CoV replication in airway epithelia.
Kun LiJennifer A BartlettChristine L Wohlford-LenaneBiyun XueAndrew L ThurmanThomas M GallagherAlejandro A PezzuloPaul B McCrayPublished in: The Journal of infectious diseases (2023)
Our results suggest that increased DPP4 abundance is likely not the primary mechanism leading to increased MERS severity in the setting of Th2 inflammation. Transcriptional profiling analysis highlighted the complexity of IL-13 induced changes in airway epithelia, including altered expression of genes involved in innate immunity, antiviral responses, and maintenance of the extracellular mucus barrier. These data suggest that additional factors likely interact with DPP4 abundance to determine MERS-CoV infection outcomes.
Keyphrases
- respiratory syndrome coronavirus
- sars cov
- antibiotic resistance genes
- oxidative stress
- coronavirus disease
- diabetic rats
- poor prognosis
- gene expression
- high glucose
- wastewater treatment
- microbial community
- type diabetes
- big data
- single cell
- drug induced
- machine learning
- anaerobic digestion
- long non coding rna
- deep learning
- adipose tissue
- stress induced