Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR/Cas9 system.

Jinxin MiaoTianfeng LanHaoran GuoJianyao WangGuangtao ZhangZheng WangPanpan YangHaoze LiChunyang ZhangYaohe WangXiu-Min LiMingsan Miao

Published in: Animal models and experimental medicine (2022)

A novel SHARPIN KO hamster was successfully established using the CRISPR/Cas9 system. Abnormal development of secondary lymphoid organs and eosinophil infiltration in multiple organs reveal its potential in delineating SHARPIN function and chronic inflammation.

Keyphrases

crispr cas
genome editing
oxidative stress
genome wide
single cell
gene expression
wild type