Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer's disease.

Despoina CharouThanasis RogdakisAlessia LatorrataMaria ValcarcelVasileios PapadogiannisChristina AthanasiouAlexandros TsengenesMaria Anna PapadopoulouDimitrios LypitkasMatthieu D LavigneTheodora KatsilaRebecca C WadeM Zameel CaderTheodora CalogeropoulouAchille GravanisIoannis Charalampopoulos

Published in: Stem cell research & therapy (2024)

Our work characterizes a novel BDNF mimetic with preferable pharmacological properties and neurogenic and neuroprotective actions in Alzheimer's disease via stem cell-based screening, demonstrating the promise of stem cell systems for short-listing competitive candidates for further testing.

Keyphrases

stem cells
spinal cord injury
endothelial cells
cognitive decline
cell therapy
big data
mesenchymal stem cells
induced pluripotent stem cells
pluripotent stem cells
deep learning