Elevated interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a poor prognostic marker in pancreatic ductal adenocarcinoma.
Yue ZhaoAnnelore Altendorf-HofmannIoannis PoziosPeter CamajTherese DäberitzXiaoyan WangHanno NiessHendrik SeeligerFelix PoppChristopher BetzlerUtz SettmacherKarl-Walter JauchChristiane BrunsThomas KnöselPublished in: Journal of cancer research and clinical oncology (2017)
High expression of IFIT3 enhances anti-apoptotic activity and chemotherapy resistance of PDAC cells. High expression of IFIT3 was independently correlated to shorter patients' survival and may serve as a prognostic marker.
Keyphrases
- poor prognosis
- end stage renal disease
- ejection fraction
- binding protein
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- cell death
- prognostic factors
- cell cycle arrest
- peritoneal dialysis
- radiation therapy
- locally advanced
- signaling pathway
- protein protein
- oxidative stress
- patient reported outcomes
- cell proliferation
- rectal cancer
- pi k akt