Prognostic and predictive value of the combination of TOP2A and HER2 in node-negative tumors 2 cm or smaller (T1N0) breast cancer.

Wenjing ZhongYaping YangAiling ZhangWanyi LinGehao LiangYun LingJiajie ZhongJuanjuan YongZihao LiuZhenluan TianQun LinQing LuoYangyang LiChang Gong

Published in: Breast cancer (Tokyo, Japan) (2020)

Patients with both HER2+ and high expression level of TOP2A protein predicts poor prognosis in T1N0 breast cancer patients. Patients with double positive for TOP2A protein and HER2 may benefit from anthracycline-based regimens.

Keyphrases

poor prognosis
long non coding rna
protein protein
amino acid
lymph node
young adults