Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis.
Han-Yang YueWei PengJun ZengYang ZhangYu WangHua JiangPublished in: Journal of intensive care (2024)
Permissive underfeeding may reduce ICU mortality in critically ill patients and help to shorten mechanical ventilation duration, but the overall mortality is not improved. Owing to the sample size and patient heterogeneity, the conclusions still need to be verified by well-designed, large-scale RCTs. Trial Registration The protocol for our meta-analysis and systematic review was registered and recorded in PROSPERO (registration no. CRD42023451308). Registered 14 August 2023.
Keyphrases
- systematic review
- meta analyses
- mechanical ventilation
- intensive care unit
- randomized controlled trial
- study protocol
- acute respiratory distress syndrome
- cardiovascular events
- clinical trial
- phase iii
- case report
- respiratory failure
- cardiovascular disease
- extracorporeal membrane oxygenation
- case control
- placebo controlled