Vaccination with a co-expression DNA plasmid containing GAD65 fragment gene and IL-10 gene induces regulatory CD4(+) T cells that prevent experimental autoimmune diabetes.
Xinyuan LiuSong ZhangXia LiPeilin ZhengFang HuZhiguang ZhouPublished in: Diabetes/metabolism research and reviews (2016)
Our data suggested that SGAD65190-315 /IL-10 DNA vaccine had protective effects on T1D by upregulating autoantigen-reactive Tregs. Our findings may provide a novel preventive therapy for T1D. Copyright © 2016 John Wiley & Sons, Ltd.
Keyphrases
- circulating tumor
- cell free
- copy number
- genome wide
- single molecule
- type diabetes
- poor prognosis
- escherichia coli
- cardiovascular disease
- genome wide identification
- multiple sclerosis
- electronic health record
- crispr cas
- nucleic acid
- glycemic control
- big data
- dna methylation
- drug induced
- binding protein
- metabolic syndrome
- long non coding rna
- adipose tissue