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The HCM - Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC - cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation.

Melissa L LynnJesus JimenezRomi L CastilloMatthew M KlassCatherine VasquezAnthony BaldoCyonna GibsonAnne M MurphyJil C Tardiff
Published in: bioRxiv : the preprint server for biology (2023)
These data indicate that the early diastolic dysfunction observed in a subset of HCM is likely attributable to structural changes at the cTnC-cTnI interface that impair accessibility of PKA thereby blunting β-adrenergic responsiveness and identifying a potential molecular target for therapeutic intervention.
Keyphrases
  • hypertrophic cardiomyopathy
  • left ventricular
  • randomized controlled trial
  • single molecule
  • blood pressure
  • electronic health record
  • oxidative stress
  • big data
  • heart failure
  • human health
  • climate change