Spatial analysis of cluster randomised trials: a systematic review of analysis methods.
Christopher I JarvisGian Luca Di TannaDaniel LewisNeal AlexanderW John EdmundsPublished in: Emerging themes in epidemiology (2017)
There have been a few attempts to control and estimate spatial effects within the context of human CRTs, but our overall understanding is limited. Although spatial effects may bias trial results, their consideration was usually a supplementary, rather than primary analysis. Further work is required to evaluate and develop the spatial methodologies relevant to a range of CRTs.