Comparison of Molecular Assays for HPV Testing in Oropharyngeal Squamous Cell Carcinomas: A Population-Based Study in Northern Ireland.
Stephanie G CraigLesley A AndersonMichael MoranLaura GrahamKeith CurrieKeith RooneyMax RobinsonVictoria BinghamKate S CuschieriStephen McQuaidAndrew Graeme SchacheTerence M JonesDennis McCanceManuel Salto-TellezSimon S McDadeJacqueline A JamesPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2019)
As p16 IHC is a relatively inexpensive, accessible, and sensitive test for stratifying patients by HPV status, this study finds that more patients would benefit from first-line p16 IHC followed by specific HPV testing using HPV RNA-ISH to confirm HPV status.