Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus.

Hye Won LeeSun Ju LeeMin Young LeeMi Wha ParkSang Sik KimNari ShinDavid H LovettSun Sik BaeJinhee AhnJin-Sup ParkJun Hyok OhJung Hyun ChoiHan Cheol LeeKwang Soo ChaTaek Jong HongSang Heon Song

Published in: PloS one (2019)

Two isoforms of MMP-2 were induced by high glucose stimulation in vitro and in a Type 1 DM mouse heart model. Further study is required to examine the role of these isoforms in DM CMP.

Keyphrases

high glucose
endothelial cells
glycemic control
poor prognosis
heart failure
left ventricular
adipose tissue
cell migration
weight loss
insulin resistance