PET imaging of the influence of physiological and pathological α-synuclein on dopaminergic and serotonergic neurotransmission in mouse models.

Elise LevigoureuxCaroline BouillotThierry BaronLuc ZimmerSophie Lancelot

Published in: CNS neuroscience & therapeutics (2018)

This PET study highlights an effect of α-syn modulation on the expression of the D2 receptor, whereas aggregated α-syn leads to overexpression of 5-HT1A receptor, as a pathophysiological signature.

Keyphrases

pet imaging
positron emission tomography
mouse model
poor prognosis
computed tomography
transcription factor