High-resolution maps of enhancer-promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes. This represents an important step forward for mapping genes involved in complex diseases.
Keyphrases
- high resolution
- coronary artery
- genome wide
- cardiovascular disease
- transcription factor
- endothelial cells
- genome wide identification
- dna methylation
- bioinformatics analysis
- pulmonary artery
- copy number
- gene expression
- multiple sclerosis
- induced pluripotent stem cells
- binding protein
- mass spectrometry
- type diabetes
- genome wide analysis
- peripheral blood
- pulmonary hypertension
- metabolic syndrome
- pluripotent stem cells
- cardiovascular risk factors
- drug induced
- tandem mass spectrometry