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Isolating the effect of confounding from the observed survival benefit of screening participants - a methodological approach illustrated by data from the German mammography screening programme.

Laura BuschmannIna WellmannNadine BonbergJürgen WellmannHans-Werner HenseAndré KarchHeike Minnerup
Published in: BMC medicine (2024)
This study shows that, in addition to stage shift, lead and length time bias, confounding is an essential component when comparing the survival of MSP participants and non-participants. We further show that the confounding effect can be quantified without explicit knowledge of potential confounders by using a negative control outcome.
Keyphrases
  • healthcare
  • free survival
  • randomized controlled trial
  • big data
  • magnetic resonance imaging
  • computed tomography
  • magnetic resonance
  • human health
  • image quality