Hyperoside Inhibits RNF8-mediated Nuclear Translocation of β-catenin to Repress PD-L1 Expression and Prostate Cancer.

Song TanXiaoli WangDengke Yin

Published in: Anti-cancer agents in medicinal chemistry (2024)

Hyperoside exerts its anti-PCa effect by reducing RNF8 protein, inhibiting nuclear translocation of β-catenin, and disrupting the Wnt/β-catenin pathway, in turn reducing the expression of PD-L1 and improving Jurkat cell immunity.

Keyphrases

prostate cancer
cell proliferation
epithelial mesenchymal transition
poor prognosis
radical prostatectomy
binding protein
single cell
stem cells
dna damage response
signaling pathway
cell therapy
sensitive detection
protein protein
living cells
amino acid
oxidative stress
bone marrow
quantum dots