The adverse impact of ecotropic viral integration site-1 (EVI1) overexpression on the prognosis of acute myeloid leukemia with KMT2A gene rearrangement in different risk stratification subtypes.

Xin-Xin LiuXin-An PanMeng-Ge GaoJun KongHao JiangYing-Jun ChangXiao-Hui ZhangYu WangKai-Yan LiuZhong ChenXiao-Jun HuangXiao-Jun Huang

Published in: International journal of laboratory hematology (2022)

Our study showed that for the Non-KMT2A-MLLT3 group, the EVI1-high group had shorter OS and DFS than the EVI1-low group. High EVI1 expression showed an adverse effect in AML with KMT2A rearrangement in different risk stratification subtypes. For the EVI1-high patients with non-KMT2A-MLLT3 rearrangement, other novel regimens towards relapse should be taken into consideration.

Keyphrases

acute myeloid leukemia
poor prognosis
sars cov
allogeneic hematopoietic stem cell transplantation
transcription factor
acute lymphoblastic leukemia
copy number
dna methylation
binding protein
electronic health record