Soluble epoxide hydrolase inhibition enhances Specialized Pro-resolving Lipid Mediator production and promotes macrophage plasticity.

Henrique Ballassani AbdallaCarla AlvarezYu-Chiao WuPaola RojasBruce D HammockKrishna R MaddipatiCarlos Antonio Trindade-da-SilvaMariana Q S SoaresJuliana T Clemente-NapimogaAlpdogan KantarciMarcelo H NapimogaThomas E Van Dyke

Published in: British journal of pharmacology (2022)

Pharmacological sEH inhibition positively impacts SPM synthesis associated with resolving macrophages, suggesting a potential target to control osteolytic inflammatory disorders.

Keyphrases

palliative care
oxidative stress
fatty acid
human health
risk assessment