The Flavonoid Glycoside from Abrus cantoniensis Hance Alleviates Alcoholic Liver Injury by Inhibiting Ferroptosis in an AMPK-Dependent Manner.
Yanqiu ZhangRuirui DongHuiling ZhouJingyi WangJianfei ShiShengtao YeYang ChengYingrong LengWenjun XuLing-Yi KongHao ZhangPublished in: Journal of agricultural and food chemistry (2024)
Abrus cantoniensis Hance is a vegetative food and can be used as a folk beverage or soup to clear liver toxins and prevent liver damage. However, the components and effects of A. cantoniensis Hance in alcohol-induced liver injury were unknown. This study aimed to obtain abundant phytochemicals from A. cantoniensis Hance and identify the potency of the isolates in preventing alcohol-induced liver injury. Alcohol-stimulated AML12 cells and Lieber-DeCarli diet-fed mice were used to establish in vitro and in vivo models, respectively. Our findings indicated that flavonoid glycosides, especially AH-15 , could significantly alleviate alcohol-induced liver injury by inhibiting oxidative stress. Furthermore, we demonstrated that AH-15 inhibited ferroptosis induced by lipid peroxidation. Mechanically, we found that AH-15 regulated nuclear factor erythroid 2-related factor 2 (NRF2) expression via activation of AMP-activated protein kinase (AMPK) signaling. These results indicate that A. cantoniensis Hance is a great potential functional food for alleviating alcohol-induced liver injury.
Keyphrases
- protein kinase
- oxidative stress
- nuclear factor
- alcohol consumption
- induced apoptosis
- cell death
- diabetic rats
- signaling pathway
- toll like receptor
- skeletal muscle
- poor prognosis
- dna damage
- human health
- acute myeloid leukemia
- drug induced
- physical activity
- liver injury
- cell cycle arrest
- metabolic syndrome
- endothelial cells
- weight loss
- risk assessment
- mouse model
- climate change
- immune response
- inflammatory response
- adipose tissue
- acute lymphoblastic leukemia
- genetic diversity
- long non coding rna
- high fat diet induced