Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease.

Akitoyo HishimotoOlga PletnikovaDoyle Lu LangJuan C TroncosoJosephine M EganQing-Rong Liu

Published in: Alzheimer's research & therapy (2019)

We found that the SNP rs8019381 of NRXN3 that is located adjacent to splicing site #5 (SS#5) interacts with the APOE ε4 haplotype and alters NRXN3 transmembrane or soluble isoform expression in AD postmortem cortex. Dysregulation of presynaptic NRXN3 expression and splicing might increase neuron inflammation in AD brain.

Keyphrases

poor prognosis
binding protein
cognitive decline
oxidative stress
genome wide
long non coding rna
dna methylation
high fat diet
white matter
functional connectivity
resting state
metabolic syndrome