Efficacy and safety of ketamine-assisted electroconvulsive therapy in major depressive episode: a systematic review and network meta-analysis.

Taeho Greg RheeSung Ryul ShimJonah H PoppThomas A TrikalinosRobert A RosenheckCharles H KellnerStephen J SeinerRandall T EspinozaBrent P ForesterRoger S McIntyre

Published in: Molecular psychiatry (2023)

Ketamine-assisted ECT is tolerable and may be efficacious in improving depressive symptoms, but a relative adverse impact on cognition may be an important clinical consideration. Anesthetic agents should be considered based on patient profiles and/or preferences to improve effectiveness and safety of ECT use.

Keyphrases

depressive symptoms
pain management
bipolar disorder
mild cognitive impairment
social support
decision making
multiple sclerosis
adverse drug