Bazedoxifene increases the proliferation of human arterial endothelial cells but does not affect the expression of cyclins A, B, and D1 and of p27Kip1.

Darya DudenkoRaúl GómezMiguel-Ángel García-PérezJuan J TarínAntonio Cano

Published in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2021)

Bazedoxifene demonstrated a proliferative effect of similar size to estradiol in cultured human umbilical artery endothelial cells. The molecular mechanisms need further investigation.

Keyphrases

endothelial cells
high glucose
poor prognosis
vascular endothelial growth factor
signaling pathway
binding protein
estrogen receptor
long non coding rna
induced pluripotent stem cells