Wilms tumor.
Luke PaterPatrick MelchiorChristian RübeBenjamin T CooperMary Fran McAleerJohn A KalapurakalArnold C PaulinoPublished in: Pediatric blood & cancer (2020)
The objectives for the treatment of Wilms tumor in both the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) have focused on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin. Although the timing of surgery is different in COG (upfront surgery) and SIOP (upfront chemotherapy with delayed surgery), both are effective strategies and have the same survival. Fewer patients are treated with radiotherapy in the SIOP trials but with higher doses. The prognostic significance of biological markers such as 1q gain and clinical outcomes with novel radiation techniques such as intensity modulated radiation therapy will be determined in upcoming clinical trials. A closer collaboration between COG and SIOP could help promote research and improve the clinical outcomes of children with Wilms tumor.
Keyphrases
- minimally invasive
- coronary artery bypass
- radiation therapy
- clinical trial
- locally advanced
- young adults
- palliative care
- surgical site infection
- newly diagnosed
- ejection fraction
- emergency department
- oxidative stress
- prognostic factors
- coronary artery disease
- drug delivery
- randomized controlled trial
- cancer therapy
- patient reported
- double blind