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Multivalency in Rab effector interactions.

Amrita RaiRoger S GoodyMatthias Philipp Müller
Published in: Small GTPases (2017)
Rab proteins regulate vesicular transport in eukaryotic cells and establish connections to various cellular structures and processes by interacting with so-called effector molecules. Several of these effectors are known to not only bind a single Rab protein, but to be able to bind multiple different Rabs simultaneously. In this review we will give a short overview of effectors in general and (putative) functions of the aforementioned multivalent Rab:effector interactions.
Keyphrases
  • type iii
  • regulatory t cells
  • dendritic cells
  • induced apoptosis
  • cell cycle arrest
  • high resolution
  • immune response
  • small molecule
  • oxidative stress
  • mass spectrometry
  • protein protein
  • cell death