Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope.

Ding ZhaoXun GaoJiale ZhouJinze LiYuqiang QianDi WangWenchao NiuTao ZhangMingyang HuHaoyang XiongLiangxue LaiZhanjun Li

Published in: BMC biology (2023)

These novel Nme2ABE8es with increased on-target DNA editing and expanded PAM compatibility will expand the base editing toolset for efficient gene modification and therapeutic applications.

Keyphrases

crispr cas
genome editing
circulating tumor
cell free
single molecule
copy number
genome wide
nucleic acid
dna methylation