miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis.
Alberto Del MonteAna B ArroyoMaría J Andrés-ManzanoNuria García-BarberáMaría S CalepricoVicente VicenteVanessa RoldánRocío González-ConejeroConstantino MartínezVicente AndrésPublished in: PloS one (2018)
miR-146a deficiency exclusively in hematopoietic cells modulates cholesterol levels in plasma and the expression of its targets in the artery wall of fat-fed Ldlr-/- mice, but does not accelerate atherosclerosis. Atheroprotection upon systemic miR-146a administration may therefore be caused by specific effects on vascular cells.