Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol.
Wega SetiabudiDaniel James HungerfordKrishanthi SubramaniamNatasha Marcella VaselliVictoria E ShawMoon WiltonRoberto VivancosStephen J AstonGareth PlattTracy MoittAshley P JonesMark GabbayIain Edward BuchanEnitan D CarrolMiren Iturriza-GomaraTom SolomonWilliam GreenhalfDean J NaisbittEmily R AdamsNigel A CunliffeLance TurtleNeil Frenchnull nullPublished in: BMJ open (2021)
The study has received approval from the National Health Service Research Ethics Committee; REC Reference: 20/HRA/2297, IRAS Number: 283 464. Results will be disseminated through scientific conferences and peer-reviewed open access publications. A report of the findings will also be shared with participants. The study will quantify the scale and determinants of household transmission of SARS-CoV-2. Additionally, immunological responses before and during the different stages of infection will be analysed, adding to the understanding of the range of immunological response by infection severity.