Effects of estradiol on HIF-1α expression and trophoblast differentiation in first trimester villous explant cultures.

Geum Joon ChoLyn Hwa LeeBona LeeJaeeun LeeKi-Hoon AhnSoon-Cheol HongHai-Joong KimMin-Jeong Oh

Published in: Obstetrics & gynecology science (2017)

Our findings suggest that estradiol may downregulate expression of HIF-1α in placenta, which in turn promote trophoblast differentiation into invasive phenotype.

Keyphrases

poor prognosis
endothelial cells
binding protein
estrogen receptor