Role of WNT10A in failure of tooth development in humans and zebrafish.
Qiuping YuanMin ZhaoBhavna TandonLorena MailiXiaoming LiuAnqi ZhangEvan H BaughTam TranRenato M SilvaJacqueline T HechtEric C SwindellDaniel S WagnerAriadne LetraPublished in: Molecular genetics & genomic medicine (2017)
Our results reveal a novel compound heterozygous variant in WNT10A as pathogenic for oligodontia, and demonstrate that perturbations of wnt10a expression in zebrafish may directly and/or indirectly affect tooth development recapitulating the agenesis phenotype observed in humans.