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Role of WNT10A in failure of tooth development in humans and zebrafish.

Qiuping YuanMin ZhaoBhavna TandonLorena MailiXiaoming LiuAnqi ZhangEvan H BaughTam TranRenato M SilvaJacqueline T HechtEric C SwindellDaniel S WagnerAriadne Letra
Published in: Molecular genetics & genomic medicine (2017)
Our results reveal a novel compound heterozygous variant in WNT10A as pathogenic for oligodontia, and demonstrate that perturbations of wnt10a expression in zebrafish may directly and/or indirectly affect tooth development recapitulating the agenesis phenotype observed in humans.
Keyphrases
  • cell proliferation
  • stem cells
  • poor prognosis
  • early onset
  • genome wide
  • long non coding rna