Role of WNT10A in failure of tooth development in humans and zebrafish.

Qiuping YuanMin ZhaoBhavna TandonLorena MailiXiaoming LiuAnqi ZhangEvan H BaughTam TranRenato M SilvaJacqueline T HechtEric C SwindellDaniel S WagnerAriadne Letra

Published in: Molecular genetics & genomic medicine (2017)

Our results reveal a novel compound heterozygous variant in WNT10A as pathogenic for oligodontia, and demonstrate that perturbations of wnt10a expression in zebrafish may directly and/or indirectly affect tooth development recapitulating the agenesis phenotype observed in humans.

Keyphrases

cell proliferation
stem cells
poor prognosis
early onset
genome wide
long non coding rna