Fecal microbiota and volatile metabolome pattern alterations precede late-onset meningitis in preterm neonates.

Nina M Frerichs Nancy Deianova Sofia El Manouni El Hassani Animesh AcharjeeMohammed Nabil QuraishiWillem P de Boode Veerle Cossey Christian V HulzebosAnton H van KaamBoris W KramerEsther d'HaensWouter J de Jonge Daniel C Vijbrief Mirjam Maria van WeissenbruchEmma DaultonAlfian N Wicaksono James Anthony CovingtonMarc A BenningaNanne K H De Boer Johannes Hans B van Goudoever Hendrik J Niemarkt Tim G J de Meij

Published in: The Journal of infectious diseases (2024)

Infants with LOM could be accurately discriminated from controls based on preclinical microbiota composition, while alterations in the volatile metabolome were moderately associated with preclinical LOM.

Keyphrases

late onset
early onset
low birth weight
gas chromatography
cell therapy
preterm birth
preterm infants
mass spectrometry
gestational age
mesenchymal stem cells
high resolution
simultaneous determination