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A population of CD4hiCD38hi T cells correlates with disease severity in patients with acute malaria.

Simon H ApteGabriela MinigoPenny L GrovesJessie C SpargoMagdalena PlebanskiMathew J GriggEnny KenangalemJulie G BurelJessica R LoughlandKatie L FlanaganKim A PieraTimothy WilliamRic N PriceTonia WoodberryBridget E BarberNicholas M AnsteyDenise L Doolan
Published in: Clinical & translational immunology (2020)
In naturally infected adults with acute malaria, a prominent population of type 1 regulatory T cells arises that can be defined by high co-expression of CD4 and CD38 (CD4hiCD38hi) and that correlates with disease severity in patients with falciparum malaria. This study provides fundamental insights into T-cell biology, including the first evidence that CD4 expression is modulated at the mRNA level. These findings have important implications for understanding the balance between immunity and immunopathology during malaria.
Keyphrases
  • plasmodium falciparum
  • regulatory t cells
  • poor prognosis
  • nk cells
  • dendritic cells
  • liver failure
  • immune response
  • respiratory failure
  • aortic dissection
  • acute respiratory distress syndrome