Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a systematic review and meta-analysis.
Lingling DingB PengPublished in: European journal of neurology (2018)
For stroke prevention in elderly patients with IS or TIA, DAPT is superior to aspirin monotherapy but appears to be equivalent to clopidogrel monotherapy, and is accompanied by an increased risk of bleeding. The balance between the benefits and risks of DAPT is important to consider when choosing antiplatelet strategy.
Keyphrases
- antiplatelet therapy
- atrial fibrillation
- percutaneous coronary intervention
- acute coronary syndrome
- combination therapy
- open label
- coronary artery disease
- middle aged
- randomized controlled trial
- human health
- type diabetes
- cardiovascular disease
- community dwelling
- cerebral ischemia
- low dose
- risk assessment
- brain injury
- blood brain barrier
- subarachnoid hemorrhage