Association between expression of long noncoding RNAs in placenta and pregnancy features.

Aim: The contribution of long noncoding RNAs (lncRNAs) has been highlighted in a variety of human disorders including cancer and placenta-associated conditions. Methods: We evaluated expression of CCAT2, UCA1, FAS-AS1 and OIP5-AS1 lncRNAs in placenta samples obtained from normal and intrauterine growth restriction pregnancies. Results: There was no significant difference in expression of these lncRNAs between cases and controls. A significant association was found between CCAT2 expression and gravidity/parity. CCAT2 expression was higher in cases with abortion history. Cases who received folic acid had lower expression of this lncRNA. Conclusion: The current study provides evidences for association between expression of CCAT2 and clinical determinants of placenta function. Future studies are needed to elaborate the underlying mechanism.