Differential presentation of hypersensitivity reactions to carboplatin and oxaliplatin: Phenotypes, endotypes, and management with desensitization.
Teodorikez-Wilfox Jimenez-RodriguezLeticia de Las VecillasMarina LabellaDonna-Marie LynchKylie Marie BeszKathleen MarquisAmparo BurgosVictor Soriano GomisInmaculada LozanoRosa Ana Montoyo AntónFrancisco Marco de la CalleMaría Purificación González DelgadoAurora GutiérrezEstefanía MontenegroFernando RodríguezFrancisco Javier Fernández SánchezMariana CastellsPublished in: Allergy (2023)
Carboplatin and oxaliplatin induced three different types of reactions with defined phenotypes and endotypes amendable to DD. Although most of the initial reactions for both were type I, oxaliplatin presented with unique CRR reactions. During DD, carboplatin reactive patients presented mostly type I BTR, while oxaliplatin-reactive patients frequently switched from type I to CRR, providing a critical difference and the need for personalized DD protocols.