Why is congenital Zika syndrome asymmetrically distributed among human populations?
Jimena Barbeito-AndrésLavínia Schuler-FacciniPatricia Pestana GarcezPublished in: PLoS biology (2018)
Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus' genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
Keyphrases
- zika virus
- dengue virus
- endothelial cells
- aedes aegypti
- healthcare
- induced pluripotent stem cells
- pluripotent stem cells
- public health
- mental health
- genome wide
- magnetic resonance imaging
- gene expression
- risk assessment
- pregnant women
- risk factors
- climate change
- health information
- copy number
- drug induced
- human health
- case control
- health promotion