Predictive enrichment for the need of renal replacement in sepsis-associated acute kidney injury: combination of furosemide stress test and urinary biomarkers TIMP-2 and IGFBP-7.

Lars PalmowskiSimone LindauLaura Contreras HenkBritta MarkoAndrea WitowskiHartmuth NowakSandra E StollKai ZacharowskiBernd W BöttigerJürgen PetersMichael AdamzikFabian DusseTim Rahmel

Published in: Annals of intensive care (2024)

The combined application of an upstream FST followed by urinary TIMP-2*IGFBP-7 measurements supports highly specific identification of SA-AKI patients requiring RRT. Upcoming interventional trials should elucidate if this high-risk SA-AKI subgroup, identified by our predictive enrichment approach, benefits from an early RRT initiation.

Keyphrases

acute kidney injury
cardiac surgery
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
intensive care unit
clinical trial
randomized controlled trial
patient reported outcomes
septic shock
phase iii
bioinformatics analysis
double blind
placebo controlled